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human SPTLC1 shRNA silencing Adenovirus

Name 
Ad-h-SPTLC1-shRNA
Cat No 
shADV-224294
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SPTLC1.

shADV-224294
Ad-h-SPTLC1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SPTLC1 (serine palmitoyltransferase long chain base subunit 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
HSAN1; HSN1; LBC1; LCB 1; LCB1; long chain base biosynthesis protein 1; serine C-palmitoyltransferase; serine palmitoyltransferase 1; serine-palmitoyl-CoA transferase 1; SPT 1; SPT1; SPTI
Description (eCommerce)
Serine palmitoyltransferase (SPT), which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. SPTLC1 (serine palmitoyltransferase, long chain base subunit 1 is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in SPTLC1 were identified in patients with hereditary sensory neuropathy type 1 [taken from NCBI Entrez Gene (Gene ID: 10558)].
Description (Vector)
Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified.
Gene ID
10558
Gene Name (eCommerce)
serine palmitoyltransferase long chain base subunit 1
Gene Name (Vector)
serine palmitoyltransferase long chain base subunit 1
Gene Symbol
SPTLC1
HGNC ID
HGNC:11277
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1542
ORF Size (bp)
1542 bp
Protein Name (eCommerce)
Serine palmitoyltransferase 1
RefSeq ID
NM_006415
RefSeq Synonyms
NM_178324, NM_006415, NM_001281303, BC068537,
Research Areas
Acyltransferase,Immunology,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment
Research Areas (Faceted)
cell_biology,immunology,metabolism,neurobiology,developmental_biology
Species
human
Target Sentence
Serine palmitoyltransferase (SPT), which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. SPTLC1 (serine palmitoyltransferase, long chain base subunit 1 is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in SPTLC1 were identified in patients with hereditary sensory neuropathy type 1 [taken from NCBI Entrez Gene (Gene ID: 10558)].
UniGene ID
Hs.90458
UniProt ID (eCommerce)
O15269

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.