human SPTAN1 shRNA silencing Adenovirus

Name 
Ad-h-SPTAN1-shRNA
Cat No 
shADV-224290
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SPTAN1.

shADV-224290
Ad-h-SPTAN1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SPTAN1 (spectrin alpha, non-erythrocytic 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
alpha-fodrin; alpha-II spectrin; EIEE5; epididymis secretory sperm binding protein; fodrin alpha chain; NEAS; spectrin alpha chain, non-erythrocytic 1; spectrin, non-erythroid alpha chain; spectrin, non-erythroid alpha subunit; SPTA2
Description (eCommerce)
SPTAN1/Alpha II-spectrin is one of two polypeptide chains (alpha and beta) that are part of the fodrin tetramer. Fodrin functions to link actin filaments to the plasma membrane and is a major neuronal cytoskeletal protein. Fodrin has been linked to neurogenerative and autoimmune diseases.
Description (Vector)
Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.
Gene ID
6709
Gene Name (eCommerce)
spectrin alpha, non-erythrocytic 1
Gene Name (Vector)
spectrin alpha, non-erythrocytic 1
Gene Symbol
SPTAN1
HGNC ID
HGNC:11273
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
7359
ORF Size (bp)
7359 bp
Protein Name (eCommerce)
Spectrin alpha chain, non-erythrocytic 1
RefSeq ID
NM_003127
RefSeq Synonyms
NM_003127, NM_001195532, NM_001130438, BC053521,
Research Areas
Apoptosis,Axon Guidance,Cardiology,Cardiovascular,CD95/FAS Signaling,Cytoskeleton,Epilepsy,Host-Virus Interactions,Neurobiology,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,neurobiology,cardiovascular,signal_transduction,cell_biology,neurobiology,infectious_disease,neurobiology
Species
human
Target Sentence
SPTAN1/Alpha II-spectrin is one of two polypeptide chains (alpha and beta) that are part of the fodrin tetramer. Fodrin functions to link actin filaments to the plasma membrane and is a major neuronal cytoskeletal protein. Fodrin has been linked to neurogenerative and autoimmune diseases.
UniGene ID
Hs.372331
UniProt ID (eCommerce)
Q13813

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.