human SPN shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SPN.
shADV-224211
Ad-h-SPN-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SPN (sialophorin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD antigen CD43; CD43; galactoglycoprotein; GALGP; GPL115; leukocyte sialoglycoprotein; leukosialin; LSN; Sialophorin; sialophorin (gpL115, leukosialin, CD43)
Description (eCommerce)
CD43 is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, CD43 is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune respons [taken from NCBI Entrez Gene (Gene ID: 6693)].
Description (Vector)
SPN is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response.
Gene ID
6693
Gene Name (eCommerce)
sialophorin
Gene Name (Vector)
sialophorin
Gene Symbol
SPN
HGNC ID
HGNC:11249
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1203
ORF Size (bp)
1203 bp
Protein Name (eCommerce)
Leukosialin
RefSeq ID
NM_003123
RefSeq Synonyms
NM_003123, NM_001030288, BC012350,
Research Areas
Cancer,Cardiovascular,Host-Virus Interactions,Immunology,Signal Transduction
Research Areas (Faceted)
cardiovascular,cancer,signal_transduction,infectious_disease,immunology
Species
human
Target Sentence
CD43 is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, CD43 is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune respons [taken from NCBI Entrez Gene (Gene ID: 6693)].
UniGene ID
Hs.632188
UniProt ID (eCommerce)
P16150
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.