human SLC6A6 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SLC6A6.
shADV-223574
Ad-h-SLC6A6-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SLC6A6 (solute carrier family 6 member 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
TAUT
Description (Vector)
Taurine (2-aminoethanesulfonic acid) is a major intracellular amino acid in mammals. It is involved in a number of important physiologic processes, including bile acid conjugation in hepatocytes, modulation of calcium flux and neural excitability, osmoregulation, detoxification, and membrane stabilization. The cells of most organisms respond to hypertonicity by the intracellular accumulation of high concentrations of small organic solutes (osmolytes) that, in contrast to high concentrations of electrolytes, do not perturb the function of macromolecules. The renal medulla is normally the only tissue in mammals that undergoes wide shifts in tonicity. Its hypertonicity when the kidney is excreting a concentrated urine is fundamental to water conservation. The taurine content of the renal medulla of rats infused with 5% NaCl is higher than that in controls, suggesting that taurine behaves as an osmolyte in the renal medulla. Indeed, taurine functions as an osmolyte in Madin-Darby canine kidney (MDCK) cells. When MDCK cells cultured in isotonic medium are switched to hypertonic medium, their content of taurine doubles through the taking up of taurine from the medium. Taurine transport in these cells is dependent on sodium and chloride ions and is localized primarily in the basolateral plasma membrane (summary by Uchida et al., 1992 (PubMed 1518851)).(supplied by OMIM, Jan 2011)
Gene ID
6533
Gene Name (Vector)
solute carrier family 6 member 6
Gene Symbol
SLC6A6
HGNC ID
HGNC:11052
ORF Size (aa)
1863
ORF Size (bp)
1863 bp
RefSeq ID
NM_003043
RefSeq Synonyms
NM_003043, NM_001134368, NM_001134367, BC137129, BC137128,
Species
human
UniGene ID
Hs.529488
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.