human SKIL shRNA silencing Adenovirus

Name
Ad-h-SKIL-shRNA

Cat No
shADV-223044

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human SKIL.

shADV-223044

Ad-h-SKIL-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SKIL (SKI like proto-oncogene). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

SNO; SnoA; SnoI; SnoN

Description (Vector)

SKIL is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.

Gene ID

6498

Gene Name (Vector)

SKI like proto-oncogene

Gene Symbol

SKIL

HGNC ID

HGNC:10897

ORF Size (aa)

2055

ORF Size (bp)

2055 bp

RefSeq ID

NM_005414

RefSeq Synonyms

NM_005414, NM_001248008, NM_001145098, NM_001145097, BC059386,

Species

human

UniGene ID

Hs.581632

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.