human SKIL shRNA silencing AAV

Name 
AAV-h-SKIL-shRNA
Cat No 
shAAV-223044
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SKIL.

shAAV-223044
AAV-h-SKIL-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SKIL (SKI like proto-oncogene). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
SNO; SnoA; SnoI; SnoN
Description (Vector)
SKIL is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.
Gene ID
6498
Gene Name (Vector)
SKI like proto-oncogene
Gene Symbol
SKIL
HGNC ID
HGNC:10897
ORF Size (aa)
2055
ORF Size (bp)
2055 bp
RefSeq ID
NM_005414
RefSeq Synonyms
NM_005414, NM_001248008, NM_001145098, NM_001145097, BC059386,
Species
human
UniGene ID
Hs.581632

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.