human SIRT2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SIRT2.
shADV-223015
Ad-h-SIRT2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SIRT2 (sirtuin 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; regulatory protein SIR2 homolog 2; silent information regulator 2; SIR2; SIR2L; SIR2L2; SIR2-like protein 2; sir2-related protein type 2; sirtuin type 2
Description (eCommerce)
Sirt2 is one of seven members of the sirtuin family of proteins that are homologous to the yeast silent information regulator 2 (Sir2), a NAD+-dependent protein deacetylase that plays a role in lifespan in lower eukaryotes. The sirtuins are diverse in their cellular functions, and are important to the regulation of oxidative stress, and metabolism. Sirt2 is localized to the cytoplasm and functions as a NAD+-dependent tubulin and histone deacetylase. Its function is hypothesized to be important to the cell cycle.
Description (Vector)
SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
Gene ID
22933
Gene Name (eCommerce)
sirtuin 2
Gene Name (Vector)
sirtuin 2
Gene Symbol
SIRT2
HGNC ID
HGNC:10886
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1059
Protein Name (eCommerce)
NAD-dependent protein deacetylase sirtuin-2
RefSeq ID
NM_012237
RefSeq Synonyms
NM_030593, NM_012237, NM_001193286, BC003547, BC003012,
Research Areas
Cell Cycle,Cell Division,Chromatin Remodeling,Cytoskeleton,Histone Modification,Transcription Factor/Regulator,Ubiquitination
Research Areas (Faceted)
cell_biology,cell_cycle,transcription_translation,genetics
Species
human
Target Sentence
Sirt2 is one of seven members of the sirtuin family of proteins that are homologous to the yeast silent information regulator 2 (Sir2), a NAD+-dependent protein deacetylase that plays a role in lifespan in lower eukaryotes. The sirtuins are diverse in their cellular functions, and are important to the regulation of oxidative stress, and metabolism. Sirt2 is localized to the cytoplasm and functions as a NAD+-dependent tubulin and histone deacetylase. Its function is hypothesized to be important to the cell cycle.
UniGene ID
Hs.466693
UniProt ID (eCommerce)
Q8IXJ6
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.