human SIK2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SIK2.
shADV-222999
Ad-h-SIK2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SIK2 (salt inducible kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
LOH11CR1I; QIK; qin-induced kinase; Salt-inducible kinase 2; salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; serine/threonine-protein kinase SIK2; serine/threonine-protein kinase SNF1-like kinase 2; SIK-2; SNF1-like kinase 2; SNF1LK2
Description (eCommerce)
Salt-inducible protein kinase 2 (SIK2) phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Sik2 inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H0K1].
Gene ID
23235
Gene Name (eCommerce)
salt inducible kinase 2
Gene Name (Vector)
salt inducible kinase 2
Gene Symbol
SIK2
HGNC ID
HGNC:21680
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2781
ORF Size (bp)
2781 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase SIK2
RefSeq ID
NM_015191
RefSeq Synonyms
NM_015191, BC117183, BC113459,
Research Areas
Golgi Apparatus,Insulin Signaling,Kinase/Phosphatase,LKB1 Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,signal_transduction
Species
human
Target Sentence
Salt-inducible protein kinase 2 (SIK2) phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Sik2 inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H0K1].
UniGene ID
Hs.269128
UniProt ID (eCommerce)
Q9H0K1
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.