human SHC1 shRNA silencing Adenovirus

Name 
Ad-h-SHC1-shRNA
Cat No 
shADV-222930
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SHC1.

shADV-222930
Ad-h-SHC1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SHC1 (SHC adaptor protein 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
SH2 domain protein C1; SHC; SHC (Src homology 2 domain containing) transforming protein 1; SHCA; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1
Description (eCommerce)
Shc1 (src-homology domain protein C1) was originally identified as an SH2 containing proto-oncogene involved in growth factor signaling. Shc1 is functions as a signaling adapter that couples activated growth factor receptors to signaling pathways.
Description (Vector)
SHC1 encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
6464
Gene Name (eCommerce)
SHC adaptor protein 1
Gene Name (Vector)
SHC adaptor protein 1
Gene Symbol
SHC1
HGNC ID
HGNC:10840
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1110
ORF Size (bp)
1110 bp
Protein Name (eCommerce)
SHC-transforming protein 1
RefSeq ID
NM_003029
RefSeq Synonyms
NM_183001, NM_003029, NM_001202859, NM_001130041, NM_001130040, BC033925, BC014158,
Research Areas
Aging,Angiogenesis,Apoptosis,B-cell Receptor Signaling,BDNF Signaling,Breast Cancer,Cancer,Cardiac Development,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cell Cycle,Cytokine Signaling,Cytoskeleton,DNA Damage/Repair,DNA Replication,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Estrogen Signaling,Fc Receptor Signaling,FGF Signaling,Glioma,HGF Signaling,Host-Virus Interactions,Hypoxia,IGF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,Leptin Signaling,Leukemia,MAPK Signaling,MicroRNAs in Cancer,Mitochondrion,Neurobiology,Neurodevelopment,NGF Signaling,PDGF Signaling,Prolactin Signaling,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TPO Signaling,TRKA Signaling,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
Shc1 (src-homology domain protein C1) was originally identified as an SH2 containing proto-oncogene involved in growth factor signaling. Shc1 is functions as a signaling adapter that couples activated growth factor receptors to signaling pathways.
UniGene ID
Hs.433795
UniProt ID (eCommerce)
P29353

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.