human SH2D1A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SH2D1A.
shADV-222879
Ad-h-SH2D1A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SH2D1A (SH2 domain containing 1A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DSHP; EBVS; IMD5; LYP; MTCP1; SAP; SAP/SH2D1A; XLP; XLPD; XLPD1
Description (Vector)
SH2D1A encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
4068
Gene Name (Vector)
SH2 domain containing 1A
Gene Symbol
SH2D1A
HGNC ID
HGNC:10820
ORF Size (aa)
387
RefSeq ID
NM_002351
RefSeq Synonyms
NM_002351, NM_001114937, BC020732,
Species
human
UniGene ID
Hs.349094
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.