human SGSH shRNA silencing Adenovirus

Product Info

Knockdown

>50% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

SGSH

Gene Name

N-sulfoglucosamine sulfohydrolase

Gene ID

6448

Gene Synonyms

HSS; MPS3A; SFMD

ORF Size

1509 bp

RefSeq#

NM_000199

Gene Description

SGSH encodes one of several enzymes involved in the lysosomal degradation of heparan sulfate. Mutations in this gene are associated with Sanfilippo syndrome A, one type of the lysosomal storage disease mucopolysaccaridosis III, which results from impaired degradation of heparan sulfate. Transcripts of varying sizes have been reported but their biological validity has not been determined.

UniGene ID

Hs.31074

HGNC ID

HGNC:10818