human SELS shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SELENOS.
shADV-222526
Ad-h-SELS-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SELENOS (selenoprotein S). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AD-015; ADO15; SBBI8; selenoprotein S; SELS; SEPS1; tanis; valosin-containing protein-interacting membrane protein; VCP interacting membrane selenoprotein; VCP-interacting membrane protein; VIMP
Description (eCommerce)
Selenoprotein S (SELS) is involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Selenoprotein S participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. It probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BQE4].
Description (Vector)
VIMP encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Gene ID
55829
Gene Name (eCommerce)
selenoprotein S
Gene Name (Vector)
selenoprotein S
Gene Symbol
SELENOS
HGNC ID
HGNC:30396
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
570
Protein Name (eCommerce)
Selenoprotein S
RefSeq ID
NM_018445
RefSeq Synonyms
NM_203472, NM_018445, BC107774, BC005840,
Research Areas
Apoptosis,Cancer,Cell Biology,Immunology,Insulin Signaling,Metabolism/Metabolic Process,Mitochondrion,Protein Folding,Transport
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,immunology,signal_transduction,metabolism,cell_biology
Species
human
Target Sentence
Selenoprotein S (SELS) is involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Selenoprotein S participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. It probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BQE4].
UniGene ID
Hs.32148
UniProt ID (eCommerce)
Q9BQE4
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.