human SELP shRNA silencing Adenovirus

Name 
Ad-h-SELP-shRNA
Cat No 
shADV-222524
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SELP.

shADV-222524
Ad-h-SELP-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SELP (selectin P). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD antigen CD62P;CD62;CD62 antigen-like family member P;CD62P;GMP140;GMP-140;granule membrane protein 140;granule membrane protein 140kDa;granulocyte membrane protein;GRMP;LECAM3;leukocyte-endothelial cell adhesion molecule 3;PADGEM;platelet activation dependent granule-external membrane protein;platelet alpha-granule membrane protein;PSEL;P-selectin;selectin P (granule membrane protein 140kDa, antigen CD62)
Description (eCommerce)
P-Selectin, or CD62P, is a Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. It mediates the interaction of activated endothelial cells or platelets with leukocytes. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P16109].
Description (Vector)
SELP encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.
Gene ID
6403
Gene Name (eCommerce)
selectin P
Gene Name (Vector)
selectin P
Gene Symbol
SELP
HGNC ID
HGNC:10721
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2490
ORF Size (bp)
2490 bp
Protein Name (eCommerce)
P-selectin
RefSeq ID
NM_003005
RefSeq Synonyms
NM_003005, BC068533,
Research Areas
Cardiovascular,Immunology,Interleukin Signaling,Neurobiology,Signal Transduction
Research Areas (Faceted)
cardiovascular,signal_transduction,immunology,neurobiology
Species
human
Target Sentence
P-Selectin, or CD62P, is a Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. It mediates the interaction of activated endothelial cells or platelets with leukocytes. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P16109].
UniGene ID
Hs.73800
UniProt ID (eCommerce)
P16109

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.