human RPS6KB2 shRNA silencing Adenovirus

Name 
Ad-h-RPS6KB2-shRNA
Cat No 
shADV-221944
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human RPS6KB2.

shADV-221944
Ad-h-RPS6KB2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RPS6KB2 (ribosomal protein S6 kinase B2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
70 kDa ribosomal protein S6 kinase 2; KLS; p70 ribosomal S6 kinase beta; p70 S6 kinase beta; p70 S6KB; p70 S6K-beta; p70(S6K)-beta; P70-beta; P70-beta-1; P70-beta-2; p70-S6K 2; P70S6K2; p70S6Kb; ribosomal protein S6 kinase beta-2; ribosomal protein S6 kinase, 70kDa, polypeptide 2; S6 kinase-related kinase; S6K2; S6KB; S6Kbeta; S6K-beta; S6K-beta2; S6K-beta-2; S6KI(2); serine/threonine-protein kinase 14 beta; serine/threonine-protein kinase 14B; SRK; STK14B
Description (eCommerce)
Ribosomal protein S6 kinase beta 2 (S6K2) encodes a member of the ribosomal S6 kinase family that phosphorylates the 40 S ribosomal subunit protein S6 and eukaryotic translation initiation factor 4B (eIF4B). S6K2 is an isoform of the p70 S6 kinase, S6K (p70a/S6K1) and is in the PI3K and mTOR pathway.
Description (Vector)
RPS6KB2 encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
Gene ID
6199
Gene Name (eCommerce)
ribosomal protein S6 kinase B2
Gene Name (Vector)
ribosomal protein S6 kinase B2
Gene Symbol
RPS6KB2
HGNC ID
HGNC:10437
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1449
ORF Size (bp)
1449 bp
Protein Name (eCommerce)
Ribosomal protein S6 kinase beta-2
RefSeq ID
NM_003952
RefSeq Synonyms
NM_003952, BC136564, BC006106, BC000094,
Research Areas
B-cell Receptor Signaling,Breast Cancer,Cancer,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Fc Receptor Signaling,FGF Signaling,HIF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leukemia,mTOR Signaling,Neurobiology,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,SCF-KIT Signaling,Signal Transduction,TGF-beta Signaling,Translational Control,VEGF Signaling
Research Areas (Faceted)
cancer,cell_biology,immunology,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
Ribosomal protein S6 kinase beta 2 (S6K2) encodes a member of the ribosomal S6 kinase family that phosphorylates the 40 S ribosomal subunit protein S6 and eukaryotic translation initiation factor 4B (eIF4B). S6K2 is an isoform of the p70 S6 kinase, S6K (p70a/S6K1) and is in the PI3K and mTOR pathway.
UniGene ID
Hs.534345
UniProt ID (eCommerce)
Q9UBS0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.