human ROBO1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ROBO1.
shADV-221469
Ad-h-ROBO1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ROBO1 (roundabout guidance receptor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
deleted in U twenty twenty; DUTT1; H-Robo-1; roundabout homolog 1; roundabout, axon guidance receptor, homolog 1; SAX3
Description (eCommerce)
ROBO1 (Roundabout homolog 1) is the receptor for SLIT1 and SLIT2. SLIT1 and SLIT2 play a role in axonal guidance in the major forebrain by regulating axon crossing at the midline and specifying directional positioning of longitudinal axonal pathways. ROBO1 is widely expressed and may also be important to lung development. ROBO1 has been reported to have tumor suppressor activity and to be frequently inactivated in lung and breast cancers.
Description (Vector)
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
6091
Gene Name (eCommerce)
roundabout guidance receptor 1
Gene Name (Vector)
roundabout guidance receptor 1
Gene Symbol
ROBO1
HGNC ID
HGNC:10249
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4656
ORF Size (bp)
4656 bp
Protein Name (eCommerce)
Roundabout homolog 1
RefSeq ID
NM_002941
RefSeq Synonyms
NM_133631, NM_002941, NM_001145845, BC171855, BC157861, BC115022, BC115020, BC112336,
Research Areas
Angiogenesis,Axon Guidance,Axonogenesis,Immunology,Neurobiology,Neurodevelopment,Neurogenesis,Signal Transduction,Translational Control
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
ROBO1 (Roundabout homolog 1) is the receptor for SLIT1 and SLIT2. SLIT1 and SLIT2 play a role in axonal guidance in the major forebrain by regulating axon crossing at the midline and specifying directional positioning of longitudinal axonal pathways. ROBO1 is widely expressed and may also be important to lung development. ROBO1 has been reported to have tumor suppressor activity and to be frequently inactivated in lung and breast cancers.
UniGene ID
Hs.13640
UniProt ID (eCommerce)
Q9Y6N7
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.