human RNF4 shRNA silencing Adenovirus

Name
Ad-h-RNF4-shRNA

Cat No
shADV-221430

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human RNF4.

shADV-221430

Ad-h-RNF4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RNF4 (ring finger protein 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

RES4-26; SLX5; SNURF

Description (Vector)

RNF4 contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.

Gene ID

6047

Gene Name (Vector)

ring finger protein 4

Gene Symbol

RNF4

HGNC ID

HGNC:10067

ORF Size (aa)

573

RefSeq ID

NM_002938

RefSeq Synonyms

NM_002938, NM_001185010, NM_001185009, BC031935,

Species

human

UniGene ID

Hs.66394

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.