human REST shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human REST.
shADV-221014
Ad-h-REST-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human REST (RE1 silencing transcription factor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DFNA27; GINGF5; HGF5; neural-restrictive silencer factor; neuron restrictive silencer factor; NRSF; RE1-silencing transcription factor; repressor binding to the X2 box; WT6; X2 box repressor; XBR
Description (eCommerce)
RE1-Silencing Transcription Factor (REST) is a transcriptional repressor that silences neuronal gene expression in non-neuronal cells by binding to the neuron-restrictive silencer element (NRSE). REST is a Kruppel-type zinc finger transcription factor that mediates repression through its interaction with the mSin3 and CoREST corepressors and the HDAC1 and HDAC2 histone deacetylases.
Description (Vector)
REST encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described
Gene ID
5978
Gene Name (eCommerce)
RE1 silencing transcription factor
Gene Name (Vector)
RE1 silencing transcription factor
Gene Symbol
REST
HGNC ID
HGNC:9966
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3294
ORF Size (bp)
3294 bp
Protein Name (eCommerce)
RE1-silencing transcription factor
RefSeq ID
NM_005612
RefSeq Synonyms
NM_005612, NM_001193508, BC136491, BC132859,
Research Areas
Apoptosis,Cancer,Cardiac Development,Cardiology,Cardiovascular,Gene Expression,Histone Modification,Host-Virus Interactions,Huntington's Disease,Neurobiology,Neurodegeneration,Neurodevelopment,Neurogenesis,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins,Zinc-finger
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,infectious_disease,neurobiology,transcription_translation
Species
human
Target Sentence
RE1-Silencing Transcription Factor (REST) is a transcriptional repressor that silences neuronal gene expression in non-neuronal cells by binding to the neuron-restrictive silencer element (NRSE). REST is a Kruppel-type zinc finger transcription factor that mediates repression through its interaction with the mSin3 and CoREST corepressors and the HDAC1 and HDAC2 histone deacetylases.
UniGene ID
Hs.631513
UniProt ID (eCommerce)
Q13127
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.