human RDH8 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RDH8.
shADV-220969
Ad-h-RDH8-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RDH8 (retinol dehydrogenase 8 (all-trans)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PRRDH; SDR28C2
Description (Vector)
All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000 (PubMed 10753906)). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin (Rando, 2001 (PubMed 11710234)). This is a rate-limiting step in the visual cycle (Saari et al., 1998 (PubMed 9667000)).(supplied by OMIM, Mar 2008)
Gene ID
50700
Gene Name (Vector)
retinol dehydrogenase 8 (all-trans)
Gene Symbol
RDH8
HGNC ID
HGNC:14423
ORF Size (aa)
936
ORF Size (bp)
936 bp
RefSeq ID
NM_015725
RefSeq Synonyms
NM_015725, BC146479, BC140328,
Species
human
UniGene ID
Hs.675522
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.