human RAD23B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RAD23B.
shADV-220641
Ad-h-RAD23B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RAD23B (RAD23 homolog B, nucleotide excision repair protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HHR23B; HR23B; P58; RAD23, yeast homolog of, B; UV excision repair protein RAD23 homolog B; XP-C repair complementing complex 58 kDa; XP-C repair complementing protein; XP-C repair-complementing complex 58 kDa protein
Description (eCommerce)
RAD23B is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. RAD23B was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
Description (Vector)
RAD23B is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene ID
5887
Gene Name (eCommerce)
RAD23 homolog B, nucleotide excision repair protein
Gene Name (Vector)
RAD23 homolog B, nucleotide excision repair protein
Gene Symbol
RAD23B
HGNC ID
HGNC:9813
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1230
ORF Size (bp)
1230 bp
Protein Name (eCommerce)
UV excision repair protein RAD23 homolog B
RefSeq ID
NM_002874
RefSeq Synonyms
NM_002874, NM_001244724, NM_001244713, BC020973,
Research Areas
Complexome,DNA Damage/Repair,Immunology,Proteasome,Spermatogenesis
Research Areas (Faceted)
cell_biology,developmental_biology,genetics,immunology,transcription_translation
Species
human
Target Sentence
RAD23B is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. RAD23B was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
UniGene ID
Hs.521640
UniProt ID (eCommerce)
P54727
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.