human PXDN shRNA silencing Adenovirus

Name 
Ad-h-PXDN-shRNA
Cat No 
shADV-220427
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PXDN.

shADV-220427
Ad-h-PXDN-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PXDN (peroxidasin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
COPOA; D2S448; D2S448E; MG50; PRG2; PXN; VPO
Description (Vector)
Drosophila peroxidasin is an extracellular matrix-associated peroxidase (Horikoshi et al., 1999 (PubMed 10441517)). It is expressed exclusively in hemocytes derived from head mesoderm at a very early stage of differentiation. Peroxidasin exists as a homotrimer with a unique hybrid structure that combines an enzymatically functional peroxidase domain with motifs that are typically found in extracellular matrix-associated proteins. It is a secreted protein that contains a secretory recognition sequence at its N terminus. Peroxidasin catalyzes hydrogen peroxide-driven radioiodination, oxidations, and the formation of dityrosine in vitro. It is also thought to function in extracellular matrix consolidation, phagocytosis, and defense.(supplied by OMIM, Jul 2009)
Gene ID
7837
Gene Name (Vector)
peroxidasin
Gene Symbol
PXDN
HGNC ID
HGNC:14966
ORF Size (aa)
4437
ORF Size (bp)
4437 bp
RefSeq ID
NM_012293
RefSeq Synonyms
NM_012293, BC140295,
Species
human
UniGene ID
Hs.332197

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.