human PTPN13 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PTPN13.
shADV-220310
Ad-h-PTPN13-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PTPN13 (protein tyrosine phosphatase, non-receptor type 13). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL; PTP1E; PTPL1; PTPLE
Description (Vector)
PTPN13 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
Gene ID
5783
Gene Name (Vector)
protein tyrosine phosphatase, non-receptor type 13
Gene Symbol
PTPN13
HGNC ID
HGNC:9646
ORF Size (aa)
7401
ORF Size (bp)
7401 bp
RefSeq ID
NM_006264
RefSeq Synonyms
NM_080685, NM_080684, NM_080683, NM_006264, BC140777,
Species
human
UniGene ID
Hs.436142
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.