human PTPN13 shRNA silencing AAV

Name
AAV-h-PTPN13-shRNA

Cat No
shAAV-220310

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PTPN13.

shAAV-220310

AAV-h-PTPN13-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PTPN13 (protein tyrosine phosphatase, non-receptor type 13). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL; PTP1E; PTPL1; PTPLE

Description (Vector)

PTPN13 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.

Gene ID

5783

Gene Name (Vector)

protein tyrosine phosphatase, non-receptor type 13

Gene Symbol

PTPN13

HGNC ID

HGNC:9646

ORF Size (aa)

7401

ORF Size (bp)

7401 bp

RefSeq ID

NM_006264

RefSeq Synonyms

NM_080685, NM_080684, NM_080683, NM_006264, BC140777,

Species

human

UniGene ID

Hs.436142

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.