human PTBP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PTBP1.
shADV-220207
Ad-h-PTBP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PTBP1 (polypyrimidine tract binding protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HNRNP-I; HNRNPI; HNRPI; pPTB; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4
Description (Vector)
PTBP1 belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
Gene ID
5725
Gene Name (Vector)
polypyrimidine tract binding protein 1
Gene Symbol
PTBP1
HGNC ID
HGNC:9583
ORF Size (aa)
1596
ORF Size (bp)
1596 bp
RefSeq ID
NM_002819
RefSeq Synonyms
NM_175847, NM_031991, NM_031990, NM_002819, BC013694, BC004383, BC002397,
Species
human
UniGene ID
Hs.172550
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.