human PSMC6 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PSMC6.
shADV-220143
Ad-h-PSMC6-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PSMC6 (proteasome 26S subunit, ATPase 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
26S proteasome AAA-ATPase subunit RPT4; 26S proteasome regulatory subunit 10B; p42; proteasome (prosome, macropain) 26S subunit, ATPase, 6; Proteasome 26S subunit ATPase 6; proteasome subunit p42; SUG2
Description (eCommerce)
Proteasome (prosome, macropain) 26S subunit, ATPase, 6 (PSMC6) is a subunit of the 26S proteasome, a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMC6 is one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity [taken from NCBI Entrez Gene (Gene ID: 5706)].
Description (Vector)
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.
Gene ID
5706
Gene Name (eCommerce)
proteasome 26S subunit, ATPase 6
Gene Name (Vector)
proteasome 26S subunit, ATPase 6
Gene Symbol
PSMC6
HGNC ID
HGNC:9553
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1170
ORF Size (bp)
1170 bp
Protein Name (eCommerce)
26S protease regulatory subunit 10B
RefSeq ID
NM_002806
RefSeq Synonyms
NM_002806, BC005390,
Research Areas
Antigen Processing and Presentation,Apoptosis,Cell Cycle,Cell Division,Complexome,DNA Damage/Repair,Gene Expression,Host-Virus Interactions,Immunology,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,Parkinson's Disease,Parkin-Ubiquitin Proteasomal System,Proteasome,RNA Processing,Ubiquitination
Research Areas (Faceted)
cell_cycle,genetics,transcription_translation,infectious_disease,immunology,metabolism,neurobiology,cell_biology
Species
human
Target Sentence
Proteasome (prosome, macropain) 26S subunit, ATPase, 6 (PSMC6) is a subunit of the 26S proteasome, a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMC6 is one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity [taken from NCBI Entrez Gene (Gene ID: 5706)].
UniGene ID
Hs.718586
UniProt ID (eCommerce)
P62333
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.