human PSEN1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PSEN1.
shADV-220067
Ad-h-PSEN1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PSEN1 (presenilin 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AD3; FAD; PS-1; PS1; S182
Description (Vector)
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Gene ID
5663
Gene Name (Vector)
presenilin 1
Gene Symbol
PSEN1
HGNC ID
HGNC:9508
ORF Size (aa)
1392
ORF Size (bp)
1392 bp
RefSeq ID
NM_000021
RefSeq Synonyms
NM_007318, NM_000021, BC011729,
Species
human
UniGene ID
Hs.3260
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.