human PRCP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PRCP.
shADV-219745
Ad-h-PRCP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PRCP (prolylcarboxypeptidase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HUMPCP; PCP
Description (Vector)
PRCP is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Gene ID
5547
Gene Name (Vector)
prolylcarboxypeptidase
Gene Symbol
PRCP
HGNC ID
HGNC:9344
ORF Size (aa)
1491
ORF Size (bp)
1491 bp
RefSeq ID
NM_005040
RefSeq Synonyms
NM_199418, NM_005040, NM_001319214, BC001500,
Species
human
UniGene ID
Hs.523936
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.