human PPP4R1 shRNA silencing Adenovirus

Name 
Ad-h-PPP4R1-shRNA
Cat No 
shADV-219682
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PPP4R1.

shADV-219682
Ad-h-PPP4R1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PPP4R1 (protein phosphatase 4 regulatory subunit 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
MEG1; PP4(Rmeg); PP4R1; serine/threonine phosphatase 4; serine/threonine-protein phosphatase 4 regulatory subunit 1
Description (eCommerce)
PPP4R1 is a regulatory subunit associated with the PP4 serine/threonine protein phosphatase catalytic subunit PPP4C. PPP4C is structurally related to PP2AC but does not associate with the same regulatory subunits. PPP4C associates with either the PPP4R1 or PPP4R2 regulatory subunit. The PPP4C/PPP4R1 phosphatase has been demonstrated to co-purify with histone deacetylase HDAC and regulate its activity.
Description (Vector)
PPP4R1 encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants.
Gene ID
9989
Gene Name (eCommerce)
protein phosphatase 4 regulatory subunit 1
Gene Name (Vector)
protein phosphatase 4 regulatory subunit 1
Gene Symbol
PPP4R1
HGNC ID
HGNC:9320
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2802
ORF Size (bp)
2802 bp
Protein Name (eCommerce)
Serine/threonine-protein phosphatase 4 regulatory subunit 1
RefSeq ID
NM_005134
RefSeq Synonyms
NM_005134, NM_001042388, BC060829,
Research Areas
Kinase/Phosphatase,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
PPP4R1 is a regulatory subunit associated with the PP4 serine/threonine protein phosphatase catalytic subunit PPP4C. PPP4C is structurally related to PP2AC but does not associate with the same regulatory subunits. PPP4C associates with either the PPP4R1 or PPP4R2 regulatory subunit. The PPP4C/PPP4R1 phosphatase has been demonstrated to co-purify with histone deacetylase HDAC and regulate its activity.
UniGene ID
Hs.464595
UniProt ID (eCommerce)
Q8TF05

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.