human PPP1CC shRNA silencing Adenovirus

Name 
Ad-h-PPP1CC-shRNA
Cat No 
shADV-219601
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PPP1CC.

shADV-219601
Ad-h-PPP1CC-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PPP1CC (protein phosphatase 1 catalytic subunit gamma). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
PP1C; PP-1G; PPP1G; protein phosphatase 1, catalytic subunit, gamma isoform; protein phosphatase 1, catalytic subunit, gamma isozyme; protein phosphatase 1C catalytic subunit; serine/threonine phosphatase 1 gamma; serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Description (eCommerce)
Protein phosphatase 1 (PP1) is a major eukaryotic serine/threonine phosphatase that is involved in a multitude of cellular functions. PP1 is a holoenzyme that consists of the PP1 catalytic subunit (PP1c) that associates with and is regulated by over 50 regulatory subunits. There are several gene and alternative splice products of the catalytic subunit PP1c. PPP1CC encodes the PP1 gamma catalytic subunit. In addition to PP1 gamma, there are two splice variants of PP1 alpha (PPP1CA), and a PP1 beta (PPP1CB) form. The mutually exclusive interaction between the various catalytic and regulatory subunits allows the PP1 enzyme to be involved in a variety of functions which include cell division, glycogen metabolism, muscle contractility, and protein synthesis. serine/threonine-protein phosphatase PP1-gamma catalytic subunit, PP-1G, PPP1G.
Description (Vector)
PPP1CC belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
5501
Gene Name (eCommerce)
protein phosphatase 1 catalytic subunit gamma
Gene Name (Vector)
protein phosphatase 1 catalytic subunit gamma
Gene Symbol
PPP1CC
HGNC ID
HGNC:9283
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
972
ORF Size (bp)
972 bp
Protein Name (eCommerce)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
RefSeq ID
NM_002710
RefSeq Synonyms
NM_002710, NM_001244974, BC014073,
Research Areas
Cancer,Cardiovascular,Cell Cycle,Cell Division,Cytoskeleton,Hippo Signaling,Host-Virus Interactions,Insulin Signaling,Kinase/Phosphatase,Meiosis,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Phosphatase,Signal Transduction,TGF-beta Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
Protein phosphatase 1 (PP1) is a major eukaryotic serine/threonine phosphatase that is involved in a multitude of cellular functions. PP1 is a holoenzyme that consists of the PP1 catalytic subunit (PP1c) that associates with and is regulated by over 50 regulatory subunits. There are several gene and alternative splice products of the catalytic subunit PP1c. PPP1CC encodes the PP1 gamma catalytic subunit. In addition to PP1 gamma, there are two splice variants of PP1 alpha (PPP1CA), and a PP1 beta (PPP1CB) form. The mutually exclusive interaction between the various catalytic and regulatory subunits allows the PP1 enzyme to be involved in a variety of functions which include cell division, glycogen metabolism, muscle contractility, and protein synthesis. serine/threonine-protein phosphatase PP1-gamma catalytic subunit, PP-1G, PPP1G.
UniGene ID
Hs.79081
UniProt ID (eCommerce)
P36873

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.