human PPP1CA shRNA silencing Adenovirus

PP1A; PP-1A; PP1alpha; PPP1A; protein phosphatase 1, catalytic subunit, alpha isoform; protein phosphatase 1, catalytic subunit, alpha isozyme; serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit; serine/threonine-protein phosphatase PP1-alpha catalytic subunit; testicular tissue protein Li 155

Protein phosphatase 1 (PP1) is a major eukaryotic serine/threonine phosphatase that is involved in a multitude of cellular functions. PP1 is a holoenzyme that consists of the PP1 catalytic subunit (PP1c) that associates with and is regulated by over 50 regulatory subunits. There are several gene and alternative splice products of the catalytic subunit PP1c. PPP1CA encodes the PP1 alpha catalytic subunit. In addition to PP1 alpha, there is PP1 beta (PPP1CB), and two splice variants of PP1 gamma (PPP1CC). The mutually exclusive interaction between the various catalytic and regulatory subunits allows the PP1 enzyme to be involved in a variety of functions which include cell division, glycogen metabolism, muscle contractility, and protein synthesis. serine/threonine-protein phosphatase PP1-alpha catalytic subunit, PPP1A, PP-1A, MGC1674, MGC15877.

PPP1CA is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.

5499

protein phosphatase 1 catalytic subunit alpha

protein phosphatase 1 catalytic subunit alpha

PPP1CA

HGNC:9281

9606.0

993

993 bp

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

NM_002708

NM_206873, NM_002708, NM_001008709, BC008010, BC004482, BC001888,

Cancer,Cardiovascular,Cell Cycle,Cell Division,Cytoskeleton,GPCR Signaling,Hippo Signaling,Host-Virus Interactions,Insulin Signaling,Kinase/Phosphatase,Meiosis,Metabolism/Metabolic Process,Neurobiology,Phosphatase,Signal Transduction,TGF-beta Signaling

cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,metabolism,neurobiology,signal_transduction

human

Protein phosphatase 1 (PP1) is a major eukaryotic serine/threonine phosphatase that is involved in a multitude of cellular functions. PP1 is a holoenzyme that consists of the PP1 catalytic subunit (PP1c) that associates with and is regulated by over 50 regulatory subunits. There are several gene and alternative splice products of the catalytic subunit PP1c. PPP1CA encodes the PP1 alpha catalytic subunit. In addition to PP1 alpha, there is PP1 beta (PPP1CB), and two splice variants of PP1 gamma (PPP1CC). The mutually exclusive interaction between the various catalytic and regulatory subunits allows the PP1 enzyme to be involved in a variety of functions which include cell division, glycogen metabolism, muscle contractility, and protein synthesis. serine/threonine-protein phosphatase PP1-alpha catalytic subunit, PPP1A, PP-1A, MGC1674, MGC15877.

Hs.183994

P62136