human PNPO shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PNPO.
shADV-219322
Ad-h-PNPO-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PNPO (pyridoxamine 5′-phosphate oxidase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HEL-S-302; PDXPO
Description (Vector)
The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy.
Gene ID
55163
Gene Name (Vector)
pyridoxamine 5'-phosphate oxidase
Gene Symbol
PNPO
HGNC ID
HGNC:30260
ORF Size (aa)
786
RefSeq ID
NM_018129
RefSeq Synonyms
NM_018129, BC006525,
Species
human
UniGene ID
Hs.631742
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.