human PHPT1 shRNA silencing Adenovirus

Name
Ad-h-PHPT1-shRNA

Cat No
shADV-218857

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human PHPT1.

shADV-218857

Ad-h-PHPT1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PHPT1 (phosphohistidine phosphatase 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

14 kDa phosphohistidine phosphatase; CGI-202; epididymis secretory sperm binding protein Li 132P; HEL-S-132P; HSPC141; Phosphohistidine phosphatase 1; PHP; PHP14; PHPT1; protein histidine phosphatase; protein janus-A homolog; sex-regulated protein janus-a

Description (eCommerce)

PHPT1 is enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. [taken from NCBI Entrez Gene (Gene ID: 29085)].

Description (Vector)

PHPT1 is an EDTA-insensitive phosphohistidine phosphatase that catalyzes the dephosphorylation of phosphopeptide I (Ek et al., 2002 (PubMed 12383260)).(supplied by OMIM, Mar 2008)

Gene ID

29085

Gene Name (eCommerce)

phosphohistidine phosphatase 1

Gene Name (Vector)

phosphohistidine phosphatase 1

Gene Symbol

PHPT1

HGNC ID

HGNC:30033

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

378

Protein Name (eCommerce)

14 kDa phosphohistidine phosphatase

RefSeq ID

NM_014172

RefSeq Synonyms

NM_014172, NM_001287343, NM_001287342, NM_001135861, BC024648,

Research Areas

Cytoskeleton,EGFR Signaling,Immunology,Kinase/Phosphatase,Metabolism/Metabolic Process,Phosphatase,Signal Transduction,T-cell Receptor Signaling

Research Areas (Faceted)

cell_biology,immunology,metabolism,signal_transduction

Species

human

Target Sentence

PHPT1 is enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. [taken from NCBI Entrez Gene (Gene ID: 29085)].

UniGene ID

Hs.409834

UniProt ID (eCommerce)

Q9NRX4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.