human PHF2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PHF2.
shADV-218811
Ad-h-PHF2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PHF2 (PHD finger protein 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CENP-35; centromere protein 35; GRC5; JHDM1E; jumonji C domain-containing histone demethylase 1E; KDM7C; lysine-specific demethylase PHF2; PHD finger protein 2
Description (eCommerce)
PHD finger protein 2 (PHF2) is a Lysine demethylase that demethylates both histones and non-histone proteins. PHF2 is enzymatically inactive by itself, and becomes active following phosphorylation by PKA. PHF2 forms a complex with ARID5B to function as a coactivator of HNF4A in liver tissue.
Description (Vector)
PHF2 encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.
Gene ID
5253
Gene Name (eCommerce)
PHD finger protein 2
Gene Name (Vector)
PHD finger protein 2
Gene Symbol
PHF2
HGNC ID
HGNC:8920
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3291
ORF Size (bp)
3291 bp
Protein Name (eCommerce)
Lysine-specific demethylase PHF2
RefSeq ID
NM_005392
RefSeq Synonyms
NM_005392, BC172560, BC172253,
Research Areas
Cancer,Chromatin Remodeling,Histone Modification,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
PHD finger protein 2 (PHF2) is a Lysine demethylase that demethylates both histones and non-histone proteins. PHF2 is enzymatically inactive by itself, and becomes active following phosphorylation by PKA. PHF2 forms a complex with ARID5B to function as a coactivator of HNF4A in liver tissue.
UniGene ID
Hs.211441
UniProt ID (eCommerce)
O75151
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.