human PGR shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PGR.
shADV-218769
Ad-h-PGR-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PGR (progesterone receptor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
NR3C3; nuclear receptor subfamily 3 group C member 3; PR; progesterone receptor
Description (eCommerce)
The progesterone receptor (PR) is a member of the steroid receptor superfamily that binds progesterone and is critical to all aspects of reproductive development and the establishment and maintenance of pregnancy. When bound by progesterone, PR enters the nucleus to function in gene-specific transcriptional activation. Progesterone receptor expression is regulated by estrogen. Recent studies have found that the status of the progesterone receptor in breast tumors may be an indicator of how tumors will respond to tamoxifen treatment.
Description (Vector)
PGR encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PGR uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap.
Gene ID
5241
Gene Name (eCommerce)
progesterone receptor
Gene Name (Vector)
progesterone receptor
Gene Symbol
PGR
HGNC ID
HGNC:8910
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2799
ORF Size (bp)
2799 bp
Protein Name (eCommerce)
Progesterone receptor
RefSeq ID
NM_000926
RefSeq Synonyms
NM_001271162, NM_001271161, NM_001202474, NM_000926, BC152914,
Research Areas
Cell Cycle,Gene Expression,Meiosis,Mitochondrion,RNA Binding,Signal Transduction,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
The progesterone receptor (PR) is a member of the steroid receptor superfamily that binds progesterone and is critical to all aspects of reproductive development and the establishment and maintenance of pregnancy. When bound by progesterone, PR enters the nucleus to function in gene-specific transcriptional activation. Progesterone receptor expression is regulated by estrogen. Recent studies have found that the status of the progesterone receptor in breast tumors may be an indicator of how tumors will respond to tamoxifen treatment.
UniGene ID
Hs.32405
UniProt ID (eCommerce)
P06401
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.