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human PDE3A shRNA silencing Adenovirus

Name 
Ad-h-PDE3A-shRNA
Cat No 
shADV-218466
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PDE3A.

shADV-218466
Ad-h-PDE3A-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PDE3A (phosphodiesterase 3A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
cAMP phosphodiesterase, myocardial cGMP-inhibited; CGI-PDE; CGI-PDE A; CGI-PDE-A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A; cyclic GMP-inhibited phosphodiesterase A; HTNB; phosphodiesterase 3A, cGMP-inhibited
Description (eCommerce)
PDE3A (cGMP-inhibited Phosphodiesterase 3A) is a cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP.
Description (Vector)
PDE3A encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
5139
Gene Name (eCommerce)
phosphodiesterase 3A
Gene Name (Vector)
phosphodiesterase 3A
Gene Symbol
PDE3A
HGNC ID
HGNC:8778
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3426
ORF Size (bp)
3426 bp
Protein Name (eCommerce)
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
RefSeq ID
NM_000921
RefSeq Synonyms
NM_001244683, NM_000921, BC117371, BC117369,
Research Areas
Apoptosis,Cardiology,Cardiovascular,Cell Cycle,GPCR Signaling,Immunology,Insulin Signaling,Leptin Signaling,Meiosis,Metabolism/Metabolic Process,Neurobiology,Signal Transduction
Research Areas (Faceted)
cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
PDE3A (cGMP-inhibited Phosphodiesterase 3A) is a cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP.
UniGene ID
Hs.591150
UniProt ID (eCommerce)
Q14432

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.