human PBK shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PBK.
shADV-218285
Ad-h-PBK-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PBK (PDZ binding kinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
cancer/testis antigen 84; CT84; epididymis luminal protein 164; HEL164; lymphokine-activated killer T-cell-originated protein kinase; MAPKK-like protein kinase; Nori-3; PDZ-binding kinase; serine/threonine protein kinase; spermatogenesis-related protein kinase; SPK; T-LAK cell-originated protein kinase; TOPK
Description (eCommerce)
PBK (PDZ binding kinase), also known as TOPK (T-LAK cell-originated protein), is a mitogen-activated protein kinase kinase (MAPKK) first identified in a yeast two-hybrid assay as a Dlg1 (disks-large)-interacting protein. PBK has been found to be up-regulated in breast cancers and highly expressed in neural stem cell cultures.
Description (Vector)
This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.
Gene ID
55872
Gene Name (eCommerce)
PDZ binding kinase
Gene Name (Vector)
PDZ binding kinase
Gene Symbol
PBK
HGNC ID
HGNC:18282
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
969
Protein Name (eCommerce)
Lymphokine-activated killer T-cell-originated protein kinase
RefSeq ID
NM_018492
RefSeq Synonyms
NM_018492, NM_001278945, BC015191,
Research Areas
Cell Cycle,Kinase/Phosphatase,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,signal_transduction
Species
human
Target Sentence
PBK (PDZ binding kinase), also known as TOPK (T-LAK cell-originated protein), is a mitogen-activated protein kinase kinase (MAPKK) first identified in a yeast two-hybrid assay as a Dlg1 (disks-large)-interacting protein. PBK has been found to be up-regulated in breast cancers and highly expressed in neural stem cell cultures.
UniGene ID
Hs.104741
UniProt ID (eCommerce)
Q96KB5
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.