human OXSR1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human OXSR1.
shADV-218031
Ad-h-OXSR1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human OXSR1 (oxidative stress responsive 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
OSR1; oxidative stress-responsive 1 protein; serine/threonine-protein kinase OSR1
Description (eCommerce)
Oxidative stress responsive 1 (OSR1) is a STE20-related kinase involved in ion transport and fluid and ion homeostasis. OSR1 interacts with SPAK (STE20/SPS1-reated proline/alanine-rich kinase) and together are activated by the upstream kinase WNK1 [with no K (lysine) protein kinase-1]. Activation of OSR1 and SPAK by WNK1 results in the phosphorylation and activation of NKCC1 (Na+-K+-2Cl- co-transporter 1) for the control of cell volume and blood pressure.
Description (Vector)
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.
Gene ID
9943
Gene Name (eCommerce)
oxidative stress responsive 1
Gene Name (Vector)
oxidative stress responsive 1
Gene Symbol
OXSR1
HGNC ID
HGNC:8508
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1584
ORF Size (bp)
1584 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase OSR1
RefSeq ID
NM_005109
RefSeq Synonyms
NM_005109, BC008726,
Research Areas
Kinase/Phosphatase,Neurobiology,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,neurobiology
Species
human
Target Sentence
Oxidative stress responsive 1 (OSR1) is a STE20-related kinase involved in ion transport and fluid and ion homeostasis. OSR1 interacts with SPAK (STE20/SPS1-reated proline/alanine-rich kinase) and together are activated by the upstream kinase WNK1 [with no K (lysine) protein kinase-1]. Activation of OSR1 and SPAK by WNK1 results in the phosphorylation and activation of NKCC1 (Na+-K+-2Cl- co-transporter 1) for the control of cell volume and blood pressure.
UniGene ID
Hs.475970
UniProt ID (eCommerce)
O95747
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.