human NUP43 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human NUP43.
shADV-217247
Ad-h-NUP43-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human NUP43 (nucleoporin 43). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
bA350J20.1; nucleoporin 43kDa; nucleoporin Nup43; nup107-160 subcomplex subunit Nup43; p42
Description (eCommerce)
Nucleoporin 43 (NUP43) is a component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y221].
Description (Vector)
Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 (PubMed 15146057)).(supplied by OMIM, Mar 2008)
Gene ID
348995
Gene Name (eCommerce)
nucleoporin 43
Gene Name (Vector)
nucleoporin 43
Gene Symbol
NUP43
HGNC ID
HGNC:21182
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1143
ORF Size (bp)
1143 bp
Protein Name (eCommerce)
Nucleoporin Nup43
RefSeq ID
NM_198887
RefSeq Synonyms
NM_198887, BC065028,
Research Areas
Cell Cycle,Cell Division,Gene Expression,Host-Virus Interactions,Immunology,Metabolism/Metabolic Process,mRNA Processing,mRNA Transport,Ribonucleoprotein Transport,RNA Processing,RNA Transport,Transport
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation,infectious_disease,immunology,metabolism
Species
human
Target Sentence
Nucleoporin 43 (NUP43) is a component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y221].
UniGene ID
Hs.510375
UniProt ID (eCommerce)
Q8NFH3
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.