human NRGN shRNA silencing Adenovirus

Name
Ad-h-NRGN-shRNA

Cat No
shADV-217079

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human NRGN.

shADV-217079

Ad-h-NRGN-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NRGN (neurogranin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

hng; RC3

Description (Vector)

Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.

Gene ID

4900

Gene Name (Vector)

neurogranin

Gene Symbol

NRGN

HGNC ID

HGNC:8000

ORF Size (aa)

237

RefSeq ID

NM_006176

RefSeq Synonyms

NM_006176, NM_001126181, BC002835,

Species

human

UniGene ID

Hs.524116

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.