human NRG3 shRNA silencing Adenovirus

Name
Ad-h-NRG3-shRNA

Cat No
shADV-217077

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human NRG3.

shADV-217077

Ad-h-NRG3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NRG3 (neuregulin 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

HRG3; pro-NRG3

Description (Vector)

NRG3 is a member of the neuregulin gene family. NRG3 family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. NRG3 encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.

Gene ID

10718

Gene Name (Vector)

neuregulin 3

Gene Symbol

NRG3

HGNC ID

HGNC:7999

ORF Size (aa)

2088

ORF Size (bp)

2088 bp

RefSeq ID

NM_001010848

RefSeq Synonyms

NM_001165973, NM_001165972, NM_001010848, BC136811,

Species

human

UniGene ID

Hs.125119

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.