human NRG1 shRNA silencing Adenovirus

Name
Ad-h-NRG1-shRNA

Cat No
shADV-217075

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human NRG1.

shADV-217075

Ad-h-NRG1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NRG1 (neuregulin 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1-IT2; SMDF

Description (Vector)

NRG1 was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD).

Gene ID

3084

Gene Name (Vector)

neuregulin 1

Gene Symbol

NRG1

HGNC ID

HGNC:7997

ORF Size (aa)

1923

ORF Size (bp)

1923 bp

RefSeq ID

NM_004495

RefSeq Synonyms

NM_013964, NM_013962, NM_013960, NM_013959, NM_013958, NM_013957, NM_013956, NM_004495, NM_001322207, NM_001322206, NM_001322205, NM_001322202, NM_001322201, NM_001322197, NM_001160008, NM_001160007, NM_001160005, NM_001160004, NM_001160002, NM_001160001, NM_001159999, NM_001159996, NM_001159995, BC150609, BC007675,

Species

human

UniGene ID

Hs.453951

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.