human NR1H4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human NR1H4.
shADV-217037
Ad-h-NR1H4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human NR1H4 (nuclear receptor subfamily 1 group H member 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BAR; FXR; HRR-1; HRR1; PFIC5; RIP14
Description (Vector)
NR1H4 encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
9971
Gene Name (Vector)
nuclear receptor subfamily 1 group H member 4
Gene Symbol
NR1H4
HGNC ID
HGNC:7967
ORF Size (aa)
1431
ORF Size (bp)
1431 bp
RefSeq ID
NM_005123
RefSeq Synonyms
NM_005123, NM_001206993, NM_001206992, NM_001206979, NM_001206978, NM_001206977, BC144184, BC130573,
Species
human
UniGene ID
Hs.282735
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.