human NR0B2 shRNA silencing Adenovirus

Name 
Ad-h-NR0B2-shRNA
Cat No 
shADV-217026
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human NR0B2.

shADV-217026
Ad-h-NR0B2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NR0B2 (nuclear receptor subfamily 0 group B member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
SHP; SHP1
Description (Vector)
NR0B2 is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Gene ID
8431
Gene Name (Vector)
nuclear receptor subfamily 0 group B member 2
Gene Symbol
NR0B2
HGNC ID
HGNC:7961
ORF Size (aa)
774
RefSeq ID
NM_021969
RefSeq Synonyms
NM_021969, BC030207,
Species
human
UniGene ID
Hs.427055

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.