human NPC1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human NPC1.
shADV-216947
Ad-h-NPC1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human NPC1 (NPC intracellular cholesterol transporter 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
NPC
Description (Vector)
NPC1 encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.
Gene ID
4864
Gene Name (Vector)
NPC intracellular cholesterol transporter 1
Gene Symbol
NPC1
HGNC ID
HGNC:7897
ORF Size (aa)
3837
ORF Size (bp)
3837 bp
RefSeq ID
NM_000271
RefSeq Synonyms
NM_000271, BC063302,
Species
human
UniGene ID
Hs.715623
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.