human NFRKB shRNA silencing Adenovirus

Name 
Ad-h-NFRKB-shRNA
Cat No 
shADV-216658
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human NFRKB.

shADV-216658
Ad-h-NFRKB-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NFRKB (nuclear factor related to kappaB binding protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DNA-binding protein R kappa B; DNA-binding protein R kappa-B; INO80 complex subunit G; INO80G; nuclear factor related to kappa-B-binding protein
Description (eCommerce)
NFRKB (nuclear factor related to kappa-B-binding protein) was first identified as a factor that could bind a variant NF-kappa B site in the interleukin-2 receptor alpha (IL-2R alpha) gene. NFRKB appears to be a transcription factor central to immune cell development. Evidence of this comes from the identification of NFRKB as an amplified gene in several cases of acute myeloid leukemia. Additionally, in another clinical case, a partial deletion of the chromosomal region that includes NFRKB is shown to be associated with combined cellular immunodeficiency.
Gene ID
4798
Gene Name (eCommerce)
nuclear factor related to kappaB binding protein
Gene Name (Vector)
nuclear factor related to kappaB binding protein
Gene Symbol
NFRKB
HGNC ID
HGNC:7802
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3900
ORF Size (bp)
3900 bp
Protein Name (eCommerce)
Nuclear factor related to kappa-B-binding protein
RefSeq ID
NM_006165
RefSeq Synonyms
NM_006165, NM_001143835, BC063280,
Research Areas
Cancer,DNA Damage/Repair,Immunology,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,genetics,immunology,transcription_translation
Species
human
Target Sentence
NFRKB (nuclear factor related to kappa-B-binding protein) was first identified as a factor that could bind a variant NF-kappa B site in the interleukin-2 receptor alpha (IL-2R alpha) gene. NFRKB appears to be a transcription factor central to immune cell development. Evidence of this comes from the identification of NFRKB as an amplified gene in several cases of acute myeloid leukemia. Additionally, in another clinical case, a partial deletion of the chromosomal region that includes NFRKB is shown to be associated with combined cellular immunodeficiency.
UniGene ID
Hs.530539
UniProt ID (eCommerce)
Q6P4R8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.