human NFATC4 shRNA silencing Adenovirus

Name
Ad-h-NFATC4-shRNA

Cat No
shADV-216635

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human NFATC4.

shADV-216635

Ad-h-NFATC4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NFATC4 (nuclear factor of activated T-cells 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

NFAT3; NF-AT3; NFATc4; NF-ATC4; nuclear factor of activated T-cells, cytoplasmic 4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4; T-cell transcription factor NFAT3

Description (eCommerce)

NFAT3 (nuclear factor of activated T-cells 3) plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. NFAT3 is transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. NFAT3 increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. It may also play an important role in myotube differentiation, cardiac development and hypertrophy, and in deafferentation-induced apoptosis of sensory neurons [taken from the Universal Protein Resource (UniProt) ww.uniprot.org/uniprot/Q14934].

Description (Vector)

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene ID

4776

Gene Name (eCommerce)

nuclear factor of activated T cells 4

Gene Name (Vector)

nuclear factor of activated T-cells 4

Gene Symbol

NFATC4

HGNC ID

HGNC:7778

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2709

ORF Size (bp)

2709 bp

Protein Name (eCommerce)

Nuclear factor of activated T-cells, cytoplasmic 4

RefSeq ID

NM_004554

RefSeq Synonyms

NM_004554, NM_001320043, NM_001288802, NM_001198967, NM_001198966, NM_001198965, NM_001136022, BC053855,

Research Areas

Apoptosis,Axon Guidance,BDNF Signaling,Cancer,Cardiac Development,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cytoskeleton,Host-Virus Interactions,Immunology,Neurobiology,RNA Binding,Signal Transduction,Transcription Factor/Regulator,Wnt Signaling

Research Areas (Faceted)

cancer,cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.77810

UniProt ID (eCommerce)

Q14934

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.