human NCOR1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human NCOR1.
shADV-216429
Ad-h-NCOR1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human NCOR1 (nuclear receptor corepressor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
hN-CoR; N-CoR; N-CoR1; nuclear receptor corepressor 1; PPP1R109; protein phosphatase 1, regulatory subunit 109; thyroid hormone- and retinoic acid receptor-associated corepressor 1; TRAC1
Description (eCommerce)
The nuclear Receptor corepressor protein (NCoR) mediates gene repression by interacting with nuclear receptors such as the thyroid hormone receptor, retinoic acid receptor, progesterone receptor, androgen receptor, estrogen receptor, and glucocorticoids receptor. NCoR mediates repression by associating with SIN3A/B and the histone deacetylases, HDAC1 and HDAC2, and promoting the formation of repressive chromatin structures.
Description (Vector)
NCOR1 encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. NCOR1 is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
Gene ID
9611
Gene Name (eCommerce)
nuclear receptor corepressor 1
Gene Name (Vector)
nuclear receptor corepressor 1
Gene Symbol
NCOR1
HGNC ID
HGNC:7672
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
7014
ORF Size (bp)
7014 bp
Protein Name (eCommerce)
Nuclear receptor corepressor 1
RefSeq ID
NM_006311
RefSeq Synonyms
NM_006311, NM_001190440, NM_001190438, BC172437, BC167431,
Research Areas
Cancer,Cell Cycle,Chromatin Remodeling,Gene Expression,Histone Modification,Immunology,JNK Signaling,Kinase/Phosphatase,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,Notch Signaling,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,immunology,signal_transduction,cell_biology,metabolism,neurobiology,developmental_biology,developmental_biology,signal_transduction,immunology,genetics,transcription_translation,cancer
Species
human
Target Sentence
The nuclear Receptor corepressor protein (NCoR) mediates gene repression by interacting with nuclear receptors such as the thyroid hormone receptor, retinoic acid receptor, progesterone receptor, androgen receptor, estrogen receptor, and glucocorticoids receptor. NCoR mediates repression by associating with SIN3A/B and the histone deacetylases, HDAC1 and HDAC2, and promoting the formation of repressive chromatin structures.
UniGene ID
Hs.462323
UniProt ID (eCommerce)
O75376
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.