human NCL shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human NCL.
shADV-216408
Ad-h-NCL-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human NCL (nucleolin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C23; Nsr1; nucleolin; Protein C23
Description (eCommerce)
Nucleolin (NCL) is a major nucleolar phosphoprotein that is involved in pre-RNA transcription and the synthesis and maturation of ribosomes. NCL can bind to histone H1 to induce chromatin condensation and may play an additional role in transcriptional elongation.
Description (Vector)
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.
Gene ID
4691
Gene Name (eCommerce)
nucleolin
Gene Name (Vector)
nucleolin
Gene Symbol
NCL
HGNC ID
HGNC:7667
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1449
ORF Size (bp)
1449 bp
Protein Name (eCommerce)
Nucleolin
RefSeq ID
NM_005381
RefSeq Synonyms
NM_005381, BC006516, BC006494, BC002343,
Research Areas
Angiogenesis,Immunology,RNA Binding,RNA Processing,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,genetics,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
Nucleolin (NCL) is a major nucleolar phosphoprotein that is involved in pre-RNA transcription and the synthesis and maturation of ribosomes. NCL can bind to histone H1 to induce chromatin condensation and may play an additional role in transcriptional elongation.
UniGene ID
Hs.79110
UniProt ID (eCommerce)
P19338
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.