human NCAPD3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human NCAPD3.
shADV-216383
Ad-h-NCAPD3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human NCAPD3 (non-SMC condensin II complex subunit D3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CAPD3; CAP-D3; condensin-2 complex subunit D3; hCAP-D3; hcp-6; hHCP-6; MCPH22; Non-SMC condensin II complex subunit D3
Description (eCommerce)
CAP-D3 is a subunit of the heteropentameric condensin II complex. Condensin participates in the condensation of chromosomes during cell division by facilitating positive DNA supercoiling and knotting by topoisomerase I and II, and aids in the proper segregation of sister chromatids. In the condensin II complex CAP-D3 is regulated by protein phosphatase 2A (PP2A) and may participate in centromere resolution.
Description (Vector)
Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 (PubMed 14532007)).(supplied by OMIM, Mar 2008)
Gene ID
23310
Gene Name (eCommerce)
non-SMC condensin II complex subunit D3
Gene Name (Vector)
non-SMC condensin II complex subunit D3
Gene Symbol
NCAPD3
HGNC ID
HGNC:28952
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4497
ORF Size (bp)
4497 bp
Protein Name (eCommerce)
Condensin-2 complex subunit D3
RefSeq ID
NM_015261
RefSeq Synonyms
NM_015261, BC098398, BC011408,
Research Areas
Cell Cycle,Cell Division
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
CAP-D3 is a subunit of the heteropentameric condensin II complex. Condensin participates in the condensation of chromosomes during cell division by facilitating positive DNA supercoiling and knotting by topoisomerase I and II, and aids in the proper segregation of sister chromatids. In the condensin II complex CAP-D3 is regulated by protein phosphatase 2A (PP2A) and may participate in centromere resolution.
UniGene ID
Hs.438550
UniProt ID (eCommerce)
P42695
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.