human PYCR1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PYCR1.
shADV-216115
Ad-h-PYCR1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PYCR1 (pyrroline-5-carboxylate reductase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ARCL2B; ARCL3B; P5C; P5C reductase 1; P5CR; P5CR 1; PIG45; PP222; PRO3; proliferation-inducing protein 45; PYCR; pyrroline-5-carboxylate reductase 1, mitochondrial
Description (eCommerce)
PYCR1 is a housekeeping enzyme that catalyzes the last step in proline biosynthesis. It can utilize both NAD and NADP, but has higher affinity for NAD. PYCR1 is involved in the cellular response to oxidative stress [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P32322].
Description (Vector)
PYCR1 encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.
Gene ID
5831
Gene Name (eCommerce)
pyrroline-5-carboxylate reductase 1
Gene Name (Vector)
pyrroline-5-carboxylate reductase 1
Gene Symbol
PYCR1
HGNC ID
HGNC:9721
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
516
Protein Name (eCommerce)
Pyrroline-5-carboxylate reductase 1, mitochondrial
RefSeq ID
NM_153824
RefSeq Synonyms
NM_153824, NM_006907, NM_001330523, NM_001282281, NM_001282280, NM_001282279, BC071842, BC022244, BC001504,
Research Areas
Metabolism/Metabolic Process,Mitochondrion
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
PYCR1 is a housekeeping enzyme that catalyzes the last step in proline biosynthesis. It can utilize both NAD and NADP, but has higher affinity for NAD. PYCR1 is involved in the cellular response to oxidative stress [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P32322].
UniGene ID
Hs.163451
UniProt ID (eCommerce)
P32322
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.