human MTNR1A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MTNR1A.
shADV-216030
Ad-h-MTNR1A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MTNR1A (melatonin receptor 1A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MEL-1A-R; MT1
Description (Vector)
MTNR1A encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.
Gene ID
4543
Gene Name (Vector)
melatonin receptor 1A
Gene Symbol
MTNR1A
HGNC ID
HGNC:7463
ORF Size (aa)
1053
ORF Size (bp)
1053 bp
RefSeq ID
NM_005958
RefSeq Synonyms
NM_005958, BC126299, BC126297, BC074947, BC074946,
Species
human
UniGene ID
Hs.243467
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.